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Millipore/MABT134 | Anti-VE-cadherin Antibody, clone BV6/MABT134/100 µL

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貨號: MABT134

品牌: Millipore

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Description
CatalogueNumber	MABT134
Replaces	MAB1989
Description	Anti-VE-cadherinAntibody,cloneBV6
AlternateNames	Cadherin-5 7B4Antigen
BackgroundInformation	HumanVascularEndothelial(VE)-cadherinisacalcium-dependentadhesionmoleculestrictlylocatedatcell-to-celljunctions.VE-cadherinispresentinalltypesofendothelium(veins,arteries,capillaryandlargevessels).Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells.Cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.VE-cadherinmayplayanimportantroleinendothelialcellBIOLOGythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.VE-cadherinalsoassociateswithalpha-cateninformingalinktotheCytoskeleton.

ProductInformation
Format	Purified
Control	HUVECcelllysate
Presentation	PurifiedmousemonoclonalIgG2aκinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	ThisAnti-VE-cadherinAntibody,cloneBV6isvalidatedforuseinWB,IC,FC,IH(P)forthedetectionofVE-cadherin.
KeyApplications	WesternBlotting Immunocytochemistry FlowCytometry Immunohistochemistry(Paraffin)
ApplicationNotes	ImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedVE-cadherininthecell-celljunctionsofHUVECcells. ImmunohistochemistryAnalysis:A1:10-1:20dilutionofarepresentativelotwasusedbyanindependentlaboratoryinparaffin-embeddedtissuesections.Bufferedformalinfixationisrecommendedwithafixationperiodofnolongerthan12hours.Highheatantigenretrievalincitratebuffer(Cat.No.21545)isalsosuggested.Antibodycanalsobeusedtolabelacetone-fixedcryostatsectionsorcellsusingaimmunoperoxidasestainingprotocol(eg.IHCSelect?DetectionKit,Cat.No.DAB150) FlowCytometryAnalysis:ArepresentativelotwasusedinthepresenceofCa2+.Note:UsePBS+2-5mMEDTAforcelldetachment. WesternBlotAnalysis:Non-reducingconditionsmaybeneeded,Ca2+requiredinbuffer(2-5mM).

BiologicalInformation
Immunogen	HUVECcells
Clone	BV6
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Isotype	IgG2aκ
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001786
EntrezGeneSummary	Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined.
GeneSymbol	CDH5 CD144 7B4
PurificationMethod	ProteinGPurified
UniProtNumber	P33151
UniProtSummary	FUNCTION:Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton.ActsinconcertwithKRIT1toestablishandmaintaincorrectendothelialcellpolarityandvascularlumen.TheseeffectsaremediatedbyrecruitmentandactivationoftheParpolaritycomplexandRAP1B.RequiredforactivationofPRKCZandforthelocalizationofphosphorylatedPRKCZ,PARD3,TIAM1andRAP1Btothecelljunction. SUBUNITSTRUCTURE:Interactsviacadherin5domainwithPTPRB.InteractswithTRPC4.InteractswithKRIT1. SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:Foundatcell-cellboundariesandprobablyatcell-matrixboundaries.KRIT1andCDH5reciprocallyregulatetheirlocalizationtoendothelialcell-celljunctions.
MolecularWeight	~120kDaobserved. Thecalculatedmolecularweightis82kDabutitwillrunbetween~90-140kDabecausethisproteinisglycosolated.

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Millipore/MABT134 | Anti-VE-cadherin Antibody, clone BV6/MABT134/100 µL

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