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Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

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貨號: MABT149

品牌: Millipore

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Description
CatalogueNumber	MABT149
Description	Anti-CD11b/ITAMAntibody,cloneEP1345Y,rabbitmonoclonal
AlternateNames	integrin,alphaM(complementcomponent3receptor3subunit) CellsurfaceglycoproteinMAC-1subunitalpha LeukocyteadhesionreceptorMO1 CR-3alphachain CD11antigen-likefamilymemberB integrin,alphaM(complementcomponentreceptor3,alpha alsoknownasCD11b (p170),macrophageantigenalphapolypeptide) macrophageantigenalphapolypeptide neutrophiladherencereceptoralpha-Msubunit integrinalpha-M antigenCD11b(p170) CD11bantigen Neutrophiladherencereceptor
BackgroundInformation	Integrinalpha-M(ITAM,ITGAM,CD11b,MAC-1alphasubunit,CR3alphachain)isthealphasubunitofITAM/beta-2complex(CD11b/CD18,Mac-1),aleukocyteadhesionheterodimericglycoprotein(1).ITAMbelongstointegrinalphachainfamilyanditispredominatelypresentedinhumanmyeloidcells,NK1cells,monocytes,andgranulocytes.ITAM/beta-2complexisareceptorforfibrinogen(bindingtoP1andP1peptidesofgammachain),factorX,andICAM1.ITAM/beta-2isimplicatedinadhesiveinteractionsofmonocytes,macrophages,andgranulocytes.Itisalsolinkedtomediationofcomplement-coatedparticleuptake(2).

ProductInformation
Format	DilutedCultureSupernatant
Control	TF-1celllysate
Presentation	RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectCD11b/ITAMusingthisAnti-CD11b/ITAMAntibody,cloneEP1345Y,RabbitvalidatedforuseinWB,IC,IH(P),IP,FC.
KeyApplications	WesternBlotting Immunocytochemistry Immunohistochemistry(Paraffin) Immunoprecipitation FlowCytometry
ApplicationNotes	ImmunohistochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotdetectedCD11b/ITAMinhumanspleentissue. ImmunocytochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotwasusedinIC. ImmunoprecipitationAnalysis:1:80dilutionfromarepresentativelotwasusedinIP. FlowCytometryAnalysis:1:20dilutionfromarepresentativelotwasusedinFC.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtohumanCD11b/ITAMattheC-terminus.
Epitope	C-terminus
Clone	EP1345Y
Host	Rabbit
Isotype	IgG
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	P11215
GeneSymbol	CD11B CR3A MAC-1 MAC1A SLEB6 CD11b MO1A MGC117044
PurificationMethod	Unpurified
UniProtNumber	P11215
UniProtSummary	FUNCTION:Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SUBUNITSTRUCTURE:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes. DOMAIN:TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage. INVOLVEMENTINDISEASE:GeneticvariationsinITGAMhasbeenassociatedwithsusceptibilitytosystemiclupuserythematosustype6(SLEB6)[MIM:609939].Systemiclupuserythematosus(SLE)isachronic,inflammatoryandoftenfebrilemultisystemicdisorderofconnectivetissue.Itaffectsprincipallytheskin,joints,kidneysandSEROsalmembranes.Itisthoughttorepresentafailureoftheregulatorymechanismsoftheautoimmunesystem. SEQUENCESIMILARITIES:Belongstotheintegrinalphachainfamily. Contains7FG-GAPrepeats. Contains1VWFAdomain.
MolecularWeight	~170kDaobserved

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Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

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