Sigma-Aldrich/Propyl gallate/PHR1118-1G/1G

• CAS Number 121-79-9

• Linear Formula 3,4,5-(HO)₃C₆H₂CO₂CH₂CH₂CH₃

• Molecular Weight 212.20

•  Beilstein Registry Number 1877976

•  E Number E310

•  EC Number 204-498-2

•  MDL number MFCD00002196

•  PubChem Substance ID 329823139

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO₄/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO₄/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety:

Symbol 

  GHS07