Sigma-Aldrich/Choline chloride/PHR1251-500MG/500MG

• CAS Number 67-48-1

• Linear Formula (CH₃)₃N(Cl)CH₂CH₂OH

• Molecular Weight 139.62

•  Beilstein Registry Number 3563126

•  EC Number 200-655-4

•  MDL number MFCD00011721

•  PubChem Substance ID 329823254

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Substrates

Choline acetyltransferase substrate

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Footnote

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Safety: