Sigma-Aldrich/Letrozole/PHR1540-1G/1G

• CAS Number 112809-51-5

• Empirical Formula (Hill Notation) C₁₇H₁₁N₅

• Molecular Weight 285.30

•  MDL number MFCD00866241

•  PubChem Substance ID 329823451

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Biochem/physiol Actions

Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety: