Sigma-Aldrich/Famciclovir/PHR1696-1G/1G

• CAS Number 104227-87-4

• Empirical Formula (Hill Notation) C₁₄H₁₉N₅O₄

• Molecular Weight 321.33

•  MDL number MFCD00866964

•  PubChem Substance ID 329823560

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Biochem/physiol Actions

Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6962 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety: