Sigma-Aldrich/(R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride (Pramipexole Related Compound

• CAS Number 104632-27-1

• Empirical Formula (Hill Notation) C₁₀H₁₇N₃S · 2HCl

• Molecular Weight 284.25

•  MDL number MFCD13186799

Properties:

Description:

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (ANAB Cert AT-1467), ISO GUIDES 34:2009 (ANAB Cert AR-1470).

Biochem/physiol Actions

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9409 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety:

Symbol 

  GHS07