Sigma-Aldrich/Ciclosporin for system suitability/Y0000361/

• CAS Number 59865-13-3

• Empirical Formula (Hill Notation) C₆₂H₁₁₁N₁₁O₁₂

• Molecular Weight 1202.61

•  Beilstein Registry Number 3647785

•  MDL number MFCD00274558

•  PubChem Substance ID 329830917

Properties:

Description:

Caution

Please find SDS provided by EDQM here..

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Safety:

Symbol 

  GHS07, GHS08