Sigma-Aldrich/Nicorandil/Y0001761/

• CAS Number 65141-46-0

• Empirical Formula (Hill Notation) C₈H₉N₃O₄

• Molecular Weight 211.17

•  MDL number MFCD00186520

•  PubChem Substance ID 329831558

Properties:

Description:

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the <A href="javascript:OpenWin('http://crs.edqm.eu/','height=400,width=600,scrollbars=yes,menubar=yes,resizable=1,toolbar=yes,status=yes')">EDQM reference substance catalogue</A>.

Biochem/physiol Actions

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Safety:

Symbol 

  GHS05, GHS07